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[News] Mathematical Models Reveal How Organisms Transcend The Sum Of Their Genes


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Mathematical Models Reveal How Organisms Transcend The Sum Of Their Genes

John Yin, a professor of chemical and biological engineering, developed computer models of a relatively simple virus to show that genes alone do not make an organism. With mathematical representations of the virus's known biology, he and former graduate student Kwang-il Lim demonstrate how genomic organization and regulation can have a large impact on biological outcomes. As shown in a new paper, simply shuffling the order of the five genes in the virus's genome has a huge impact on how well the virus grows and how it interacts with its simulated host cell.

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