H20, D2O and Life

[HydrogenBond]

If you look at H2O and D2O, these are both composed of hydrogen and oxygen and display all the same characteristic and anomalous affects associated with water. The numbers are slightly different, because D2O will hydrogen bond about 2-3% stronger than H2O.

 

Water and life

 

The affect of the higher hydrogen bonding strength of D2O is toxic to much of life. At 50% D2O in H20, cells are not able to undergo mitosis. It has to do with the self assembly of microtubules, which can't form their equilibrium configurations, because of the small increase in the hydrogen bonding strength of D2O.

 

A practical application of this is:

Another unique property of D2O relates to the enhancement of thermal stability of macromolecules, cells and tissues. This property has been utilized to enhance the thermostability of certain vaccines e.g., oral polio vaccine. This technology has enormous potential in tropical countries and can serve as a support system for cold chain in far remote areas where it is difficult to maintain the desired temperature. Likewise, several tissues/ organs e.g., kidneys and other biological material can be preserved without degradation or decay.

 

Nuclear India July August 2002

 

In this case, the affect of D2O on equilibrium is promote more stable shapes for storage under the stronger hydrogen bonding of D2O.

[Moontanman]

What would be your point HB?

[pamela]

Nuclear India

Drug Development and Therapy

 

The recent approval of clinical trials by the Canadian and US Agencies for deuterated drugs opens up enormous avenues for deuteration of drugs already in use in the country. This includes all classes of drugs, whose biological efficacy can be enhanced. A comprehensive programme for synthesis of deuteration of drugs, their pharmacokinetic profile and detailed pharmaco-therapeutic studies can be very rewarding. Likewise, in the area of cancer therapy, several strategies such as deuteration of anti-cancer drugs to enhance efficacy and reduce side effects, use of D2O to slow down proliferation of malignant cells and enhance BNCT or photo dynamic therapy are promising. The anti- hypertensive effects of D2O are dramatic and make a case for a detailed pharmacological evaluation of D2O

this one may need tweaking

The US issued patent U.S. Patent 5,223,269 for use of heavy water to treat hypertension (high blood pressure). A loss of blood pressure may partially explain the reported incidents of dizziness upon ingestion.

should be interesting to see how some of these studies pan out

It has been proposed that low doses of heavy water can slow the aging process by helping the body resist oxidative damage via the isotope effect.A team at the Institute for the Biology of Ageing, located in Moscow, conducted an experiment to determine the effect of heavy water on longevity using fruit flies and found that while large amounts were deadly, smaller quantities increased lifespans by up to 30%.

fountain of youth?:naughty:

 

 

Heavy water - Wikipedia, the free encyclopedia