Super Soldier Theories - Creating A 'plausible Possibility"?

[drobniak]

I think the answer is Core-Glc NAC enzyme superfamily inhibition along with enhancement of autocrinal renewal through cellular igf-1 and tgf-b production coupled with potent and half-life prolonged th1 modulators.If a mammal's immune system can be sustained under il-10 protocol for enough time while providing the above-mentioned positive environment, life can be prolonged 100%-160%.This is Can Alkoclar's theory backed by a number of researches.

 

In regards to physical enhancement myostatin inhibition is only a part but it should be achieved through follistatin expression enhancement to bind myostatin and avoid detrimental effects on connective tissue.One also needs to upregulate cholinergic/parasympathetic function through increase of acetylcholine release and enhancement of cholinergic receptor sensitivity.

 

DHEA release is another important matter,actually the main determinant since this neurosteroid regulates overall parasympathetic function , enhances hippocompal acetylcholine synthesis and release ,enhances testosterone and DHT levels ,stimulate GH/igf-1 production ,regulates insulin sensitivity and promotoes new nerve cell formation.(this is also Can Alkoclar's theory,I keep stealing ideas:):)

 

Any one has a supply of ACRON?Gh hyperagonist?

[Rade]

see this link for muscle cells, perhaps use these stem cells they talk about and have virus inject spider dna into the human cells in such a way that strong spider fibers are produced to make human muscle fibers stronger:

 

http://www.sciencedaily.com/releases/2007/05/070531120838.htm

 

See this link as a way to increase life span..cell cleaning therapy:

 

http://www.livescience.com/16845-longevity-aging-cellular-cleaning.html

[CraigD]

I think the answer is Core-Glc NAC enzyme superfamily inhibition along with enhancement of autocrinal renewal through cellular igf-1 and tgf-b production coupled with potent and half-life prolonged th1 modulators. ...

Welcome to hypography, drobniak! :)

 

Your entire first post is dense with technical terms and hard, without substantial research of them, to follow. Can you rewrite it in a more readable-to-the amateur way?

 

... This is Can Alkoclar's theory backed by a number of researches.

I wasn’t able to find, via a simple web search, more than vague references to “Alkolar’s theory”, most of them on “can you grow taller?” threads on web forums. Can you provide some references to this research?

 

see this link for muscle cells, perhaps use these stem cells they talk about and have virus inject spider dna into the human cells in such a way that strong spider fibers are produced to make human muscle fibers stronger:

The idea that spider muscles are super strong comes largely, I fear, from scifi stories and comic books like The Amazing Spider-Man, not from real biology. Spiders actually have very unusual musculoskeletal systems, in which the movement of their limbs is due to hydraulic pressure of their blood, so their key muscle is their heart. The actual strength of a spider’s leg is very small – only because their joints are mechanically efficient, and their mass tiny, are they capable of impressive feats of speed, jumping, etc.

 

See this link as a way to increase life span..cell cleaning therapy:

 

http://www.livescience.com/16845-longevity-aging-cellular-cleaning.html

This is pretty cool news, and promising of the possibility of a practical human prophylactic anti-aging therapy. I can’t imagine, though, that a military would prefer old super-soldiers, even ones maintained by good anti-aging therapy, to young ones, so don’t think this, or anti-aging therapies in general, will prove of much use to engineering super-soldiers.

[Rade]

the idea that spider muscles are super strong comes largely, I fear, from scifi stories and comic books like The Amazing Spider-Man, not from real biology.

I was not thinking of spider muscles, I was thinking of injected spider DNA into human cells that produce muscle in such a way that the spider DNA will modify the human DNA involved in formation of muscle fiber in such a way that the human cell would begin to produce a spider type silk fiber that could be linked to human muscle fiber. Spider silk fiber is 1000 x stronger than human muscle fiber...link the two together genetically and the super-soldier would have muscles that contain spider silk fibers. Such muscles could be strong enough to function as a protective armor against certain types of small projectiles such as bullets.

 

Then, concerning anti-aging therapy, this would result in the super-soldiers never aging (not having one that grows old). The link I provided relates to research now being done on telomere length during cell mitosis, which appears to be the key to understanding why cells age. If you create a biological super-soldier that never ages this would be a important advance. The link I providing could be used to help formulate the science how to genetically create a super soldier that never ages past the day it is created.

[CraigD]

the idea that spider muscles are super strong comes largely, I fear, from scifi stories and comic books like The Amazing Spider-Man, not from real biology.

I was not thinking of spider muscles, I was thinking of injected spider DNA into human cells that produce muscle in such a way that the spider DNA will modify the human DNA involved in formation of muscle fiber in such a way that the human cell would begin to produce a spider type silk fiber that could be linked to human muscle fiber. Spider silk fiber is 1000 x stronger than human muscle fiber...link the two together genetically and the super-soldier would have muscles that contain spider silk fibers. Such muscles could be strong enough to function as a protective armor against certain types of small projectiles such as bullets.

Interesting idea, growing built-in body armor rather than making and wearing it, though building it into muscles seems to have some severe drawbacks

1. Armor under your skin, rather than the usual over it, doesn’t prevent your skin from being punctured, allowing what should be inside to leak out and what should stay outside to leak in.
   
2. Modern bullet resistant armor, including the kind made of spider silk, works mostly by dissipating the energy of bullet in a way that damages the armor. This is good when you can easily replace the armor, not so good when the armor is built into your body, and damaging it injures you.
   
3. Spider silk, when expressed by cells from DNA that codes for it, forms microscopically short fibers, which don’t have any practically measurable strength at all, so just having some cells in a human body produce it wouldn’t have much effect on them. What makes it strong is being spun into long threads, a function that the spider’s spinnerets organs are very good at, though only for making very thin fibers that aren’t very strong compared to, say, ordinary human garment sewing thread.
   The biotech company Nexia has held patents for and been trying to make long, thick, strong spider silk threads, which they call “BioSteel” for about the past 10 years, using goats with spider genes inserted in them so their milk contains microscopic silk fibers. They’ve actually gotten pretty good at getting the microscopic silk from the goats, but still haven’t devised a workable “scaled up artificial spinneret” capable of producing very long fibers.
   I can’t imagine any way such a silk-spinning mechanism could be genetically engineered to spin strong silk fibers inside a living body, so as best I can tell, your scheme won’t work, even if someone wanted it to.
   
4. Even if you could get long, strong silk (or any other kind of) fibers woven into your muscles, I don’t think it’d be a good thing. Muscles are flexible and elastic, while fibers are not. Combining the two would, I think, result in a condition most similar to that experienced by people after surgery involving many internal sutures, where movement is painful and injures the muscle tissue.
   

The most practical “grow your own armor” bioengineer approach I can imagine is to engineer organs in the skin analogous to hair follicles to produce some strong fiber material, like spider silk, with some spinnerets-like organ to make it into long, strong “hair” that covers the body, the end result a sort of sasquatch/yeti super-soldier.

 

Perhaps its best that super-soldiers wear removable armor like ordinary soldiers.

 

Then, concerning anti-aging therapy, this would result in the super-soldiers never aging (not having one that grows old).

A completely effective anti-aging therapy (AKA immortality) were developed, I’m pretty sure people would be interested in getting it themselves in order to live forever, not just use it to create immortal super-soldiers.

 

The link I provided relates to research now being done on telomere length during cell mitosis, which appears to be the key to understanding why cells age.

I believe you’re thinking of another article – http://www.livescience.com/16845-longevity-aging-cellular-cleaning.html is about recent research in doing somewhat the opposite – activating old cells’ “suicide genes” to remove them from the body, rather than lengthening these cells’ telomeres so they live forever.

 

Interest in “telomerase therapy” for life extension seemed to me to peak in the mid 1990s. Subsequently, as it’s become obvious that a practical life extension therapy will need to use many different biological mechanisms, its change mostly to interest in how to suppress telomere extension in “immortal” disease cells, such as cancers.

 

The scientific challenge of biological immortality for complex multi-cellular animals like humans is proving, not unexpected to any but the most optimistic of researchers and enthusiasts, to be a hard one, unlikely to be solved soon.

 

I think it’s worth noting that some fictional treatment of “super soldiers” (The movie Blade Runner comes first and strongest to mind) conclude that, rather than wanting them to be long-lived, you’d want the opposite – artificially short life spans. One line of reasoning is that a person who can expect to live effectively forever if he or she can avoid danger would be strongly motivated to avoid danger – not a desirable trait in a soldier, who is expected to routinely confront danger, including obey orders to engage in certain death scenarios like delaying a stronger enemy to permit friendly forces to retreat.