Seaweed Infusion Responsible for the Inhibition of the AIDS Virus

[CerebralEcstasy]

From the Journals of AIDS Research and Therapy.... for those of you with an interest.

 

Inhibition of highly productive HIV-1 infection in T cells, primary

human macrophages, microglia, and astrocytes by Sargassum fusiforme

Elena E Paskaleva , Xudong Lin , Wen Li , Robin Cotter , Michael T

Klein , Emiliy Roberge , Er K Yu , Bruce W Clark , Jean-Claude

Veille , Yanze Liu , David Y-W Lee and Mario Canki

 

AIDS Research and Therapy 2006, 3:15 doi:10.1186/1742-6405-3-15

 

Published 25 May 2006

 

 

Abstract (provisional)

 

 

 

Background

 

The high rate of HIV-1 mutation and increasing resistance to

currently available antiretroviral (ART) therapies highlight the

need for new antiviral agents. Products derived from natural sources

have been shown to inhibit HIV-1 replication during various stages

of the virus life cycle, and therefore represent a potential source

of novel therapeutic agents. To expand our arsenal of therapeutics

against HIV-1 infection, we investigated aqueous extract from

Sargassum fusiforme (S. fusiforme) for ability to inhibit HIV-1

infection in the periphery, in T cells and human macrophages, and

ability to inhibit in the central nervous system (CNS), in microglia

and astrocytes.

 

Results

 

S. fusiforme extract blocked HIV-1 infection and replication by over

90% in T cells, human macrophages and microglia, and it also

inhibited pseudotyped HIV-1 (VSV/NL4-3) infection in human

astrocytes by over 70%. Inhibition was mediated against both CXCR4

(X4) and CCR5 (R5)-tropic HIV-1, was dose dependant and long

lasting, did not inhibit cell growth or viability, was not toxic to

cells, and was comparable to inhibition by the nucleoside analogue

2', 3'-didoxycytidine (ddC). S. fusiforme treatment blocked direct

cell-to-cell infection spread. To investigate at which point of the

virus life cycle this inhibition occurs, we infected T cells and CD4-

negative primary human astrocytes with HIV-1 pseudotyped with

envelope glycoprotein of vesicular stomatitis virus (VSV), which

bypasses the HIV receptor requirements. Infection by pseudotyped HIV-

1 (VSV/NL4-3) was also inhibited in a dose dependant manner,

although up to 57% less, as compared to inhibition of native NL4-3,

indicating post-entry interferences.

 

Conclusions

 

This is the first report demonstrating S. fusiforme to be a potent

inhibitor of highly productive HIV-1 infection and replication in T

cells, in primary human macrophages, microglia, and astrocytes.

Results with VSV/NL4-3 infection, suggest inhibition of both entry

and post-entry events of the virus life cycle. Absence of

cytotoxicity and high viability of treated cells also suggest that

S. fusiforme is a potential source of novel naturally occurring

antiretroviral compounds that inhibit HIV-1 infection and

replication at more than one site of the virus life cycle.

[Michaelangelica]

An Australian doctor is trying to encourage the use of lemon juice douches in developing countries to prevent the spread of aids.

see

http://www.aids.net.au/lemons-news-mary-magdalene.htm

He calls it "The Mary Magdelene" project.

 

You might also be interested in the thread I started here on Violets and cyclodides

 

Cyclotides have a range of interesting biological activities including anti-HIV and neurotensin inhibition, anti-microbial activity and insecticidal activity.

They are found in a variety of tropical plants from the Rubiaceae and Violaceae families.

google it; there are lots of references

[CerebralEcstasy]

Thanks for the information, I will take a look at the other threads. The site you provided was interesting as well. I

 

knew that they had found a certain group of prostitutes that were seemingly immune to the disease but hadn't heard much more on it from there on in.