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Posted
Cannabinoids May Inhibit Cancer Cell Invasion

 

ScienceDaily (Dec. 27, 2007) — Cannabinoids may suppress tumor invasion in highly invasive cancers, according to a study published online December 25 in the Journal of the National Cancer Institute.

 

Cannabinoids, the active components in marijuana, are used to reduce the side effects of cancer treatment, such as pain, weight loss, and vomiting, but there is increasing evidence that they may also inhibit tumor cell growth.

Cannabinoids May Inhibit Cancer Cell Invasion

  • 1 month later...
Posted

Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial.

 

 

Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial.

 

Pain. 2007 Dec 15;133(1-3):210-20

 

Authors: Nurmikko TJ, Serpell MG, Hoggart B, Toomey PJ, Morlion BJ, Haines D

 

Cannabinoids are known to have analgesic properties.

We evaluated the effect of oro-mucosal sativex, (THC: CBD), an endocannabinoid system modulator, on pain and allodynia, in 125 patients with neuropathic pain of peripheral origin in a five-week, randomised, double-blind, placebo-controlled, parallel design trial.

Patients remained on their existing stable analgesia. A self-titrating regimen was used to optimise drug administration.

Sixty-three patients were randomised to receive sativex and 62 placebo.

The mean reduction in pain intensity scores (primary outcome measure) was greater in patients receiving sativex than placebo (mean adjusted scores -1.48 points vs. -0.52 points on a 0-10 Numerical Rating Scale (p=0.004; 95% CI: -1.59, -0.32). Improvements in Neuropathic Pain Scale composite score (p=0.007), sleep NRS (p=0.001), dynamic allodynia (p=0.042), punctate allodynia (p=0.021), Pain Disability Index (p=0.003) and Patient's Global Impression of Change (p<0.001) were similarly greater on sativex vs. placebo. Sedative and gastrointestinal side effects were reported more commonly by patients on active medication.

Of all participants, 18% on sativex and 3% on placebo withdrew during the study.

An open-label extension study showed that the initial pain relief was maintained without dose escalation or toxicity for 52 weeks.

 

PMID: 17997224 [PubMed - indexed for MEDLINE]

Not a big study and other pain medication seems to have been used

I wonder what they mean by

An open-label extension study showed that the initial pain relief was maintained without dose escalation or toxicity for 52 weeks
.
Posted
I wouldn't classify/ register Marijuana as "medicine"

Raccoon

 

 

First of all, medicine in the sense implied here have not existed for 5,000 years. Only a few centuries ago in Western Europe, the entrails of animals were still consulted to determine the cause of a patient's sickness, and the cure. Honestly, I don't care what 'medicine' thinks of marijuana, if that's the kind of medicine you're talking about.

boerseum

 

Marijuana is a hybrid domesticated plant just as corn and potatoes. It has been cultivated for its medicinal properties and naturally selected for its effect for thousands of years in Asia.

At the same time hemp came to be by being selected for its strong fiber, thus two new domesticated plants came into being.

 

The use of medicines actually predates modern man, even animals use medicinal plant and they even seek out plants to get stoned.:eek_big:

Posted

I hope I am not Being redundant here I have not read the whole thread, but this is a really good article.

 

Conducting Scientific Research on Cannabinoids

Interviews with Dr. Robert Melamede Ph.D. (starting Nov. 2001)

Dr. Robert J. Melamede Ph.D.

Chairman of the Biology Department of the University of Colorado

Phone 719-262-3135

 

The Cannabinoid System has been around for over 600 million years. Before the Dinosaurs. The Cannabinoid System is continuously evolutioning and has been retained by all new species. Food and feeding is at the heart of the Cannabinoid System....

 

More at Cannabis and Cannabinoids

 

Content © 2000-2004. Family Council on Drug Awareness (FCDA), El Cerrito CA

Posted
I hope I am not Being redundant here I have not read the whole thread, but this is a really good article.

What an amazing article!

Thankyou

Do you have the URL/ WWW address for it?

 

I only recently discovered that we have Cannabinoid receptors ( as we do opiate ones) in the brain. I have never heard such a complete and amazing explanation of what they do.

Sounds like we should be putting it in the water supply along with fluoride :hihi:

How much can we trust the author do you think?

 

Two recent new scientist articles

 

Cannabis-based boost for smokers' suffering sperm

* 12:01 24 October 2006

 

A synthetic chemical based on those found in marijuana may fix a problem that, paradoxically, affects the sperm of cigarette smokers.

 

A new synthetic cannabinoid appears to restore the ability of the sperm to bind to the outside of human eggs. The finding is unexpected since smoking marijuana itself appears to decrease male fertility, the researchers say.

Cannabis-based boost for smokers' suffering sperm - drugs-alcohol - 24 October 2006 - New Scientist

 

 

Hope for cannabis-based drug for Alzheimer's

 

* 18:40 18 October 2006

* NewScientist.com news service

* Roxanne Khamsi, Atlanta

 

 

A compound derived from marijuana might one day help fight the memory loss associated with Alzheimer’s disease, a new study suggests.

 

Researchers have shown that a synthetic drug similar to cannabis can help older rats perform better on a spatial memory task.

. . .

The results are impressive particularly because of the low dose of drug used in the experiment, comments Ken Mackie at the University of Washington in Seattle, US, who was not involved in the study.

 

"They gave them a relatively low dose, even for a rat." Mackie says that this aspect of the study makes the prospect of developing a similar treatment for humans with Alzheimer's disease "more promising".

 

Wenk cautions, however, that WIN-55212-2 still causes psychoactive effects similar to cannabis, and as such is not yet a candidate for human use. Researchers are currently trying to develop a similar drug that could control inflammation in the brain without a concomitant high.

Why?

Hope for cannabis-based drug for Alzheimer's - drugs-alcohol - 18 October 2006 - New Scientist

  • 2 weeks later...
Posted

Doctors group backs marijuana for medical uses

Fri Feb 15, 2008 5:56pm EST

 

Related News

FDA would let drug makers tip doctors to other uses

15 Feb 2008

Medical marijuana users can be fired: Calif. court

24 Jan 2008

 

 

By Will Dunham

WASHINGTON (Reuters) - A leading U.S. doctors group has endorsed using marijuana for medical purposes, urging the government to roll back a prohibition on using it to treat patients and supporting studies into its medical applications.

 

The American College of Physicians, the second-largest doctors group in the United States, issued a policy statement on medical marijuana this week after it was approved by its governing body, the group said on Friday.

 

The group cited evidence that marijuana is valuable in treating severe weight loss associated with AIDS, and nausea and vomiting associated with chemotherapy in cancer patients.

"Additional research is needed to clarify marijuana's therapeutic properties and determine standard and optimal doses and routes of delivery.

Doctors group backs marijuana for medical uses | Health | Reuters

Posted

edited due to online bullying

See also

Parkinsons' Helped By Marijuana-Lke Chemicals In Brain

Main Category: Parkinson's Disease

Also Included In: Neurology / Neuroscience

Article Date: 11 Feb 2007 - 11:00 PST

 

 

Marijuana-like chemicals in the brain may point to a treatment for the debilitating condition of Parkinson's disease.

 

In a study published in Nature, researchers from the Stanford University School of Medicine report that endocannabinoids, naturally occurring chemicals found in the brain that are similar to the active compounds in marijuana and hashish, helped trigger a dramatic improvement in mice with a condition similar to Parkinson's

Parkinsons' Helped By Marijuana-Lke Chemicals In Brain

 

'Natural marijuana' may treat brain disorders

Marijuana

The brain chemical is similar to marijuana

Scientists hope to use a marijuana-like chemical in the brain to treat Parkinson's Disease and schizophrenia.

BBC News | HEALTH | 'Natural marijuana' may treat brain disorders

 

THE ROLE OF CANNABINOIDS IN NEURODEOENERATIVE DISEASES

MICHELLE GLASS

http://www.qmc.ufsc.br/qmcweb/artigos/maconha/papers/neurodegeneratives_diseases_cannabis.pdf

Posted
USA to get Marijuana vending Machines

Vending machines distributing the drug marijuana are to begin operating in the US state of California.

The machines can only be used by people who have been prescribed the drug for health reasons.

 

Patients will have to provide a prescription, and be fingerprinted and photographed before being allowed to use the facilities.

 

Eleven US states allow the medicinal use of marijuana, primarily for pain relief, but it remains controversial.

US to get Marijuana vending Machines - WhatsTheCrack.net

Posted

Part of me wonders if those vending machines were inspired by the attacks on pharmacies who provide medical marajuana... otherwise good and kind business people working the pharmacy losing their life's blood due to some random terrorist-esque action of the "self-righteous" religious type of even the DEA. ... So long as these machines don't end up in or near schools, I find the idea very inspiring. :confused:

Posted

Say hypothetically MJ was determined to be a useful drug thereby making its less subjectively evil. The result would be those who were the worse persecutors, based on the obsolete data, could face the possibility of looking like criminals, for their willingness to overreact to something that turned out not to be not as bad as it had been previously thought. An analogy is the good soldier who took a little too much pleasure following the orders that allowed them to over react. The 20/20 hindsight might make what had been socially acceptable behavior, look criminal. The result could be crimes against humanity type trials. For most, it may be better to not let the cows come home just yet, until they work out a deal.

 

A good analogy were the Salem witch trials. It was against the law to be a witch. But there were many who took too much pleasure being cruel. The law gave them cover for their sadistic pleasure. If the law had changed so people closer in time saw the witches as just earthy folk, those same sadists would no longer have the cover of law, but would look criminal. The witches performed a victimless crime, maybe hurting themselves with their home made remedies. The legal group had extreme victimization in mind. If you take away the subjectivities of the times and look at the results with a sense of historical perspective who were the real criminals?

  • 3 weeks later...

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