Alzheimer's? Why?

[nutronjon]

I have been told that keeping the brain attactive also delays cognitive deterioration. Which would make sense considering blood goes where the brain is active. The exercise improves our circulation. Looks to me we need to do everything we can to keep that blood flowing through our brains. Hardening of the arteries that would reduce flow to the brain, needs to be avoided. I can see where in a sluggish blood system, would allow plague to build up.

 

People who become insensitive to the smell of clorox are at higher risk of getting Alzhiemers. This concerns me a lot as my ability to smell is very bad. Any idea why smell would be associated with the disease? Could it be the location of this function, in relation to memory functions, that results in the connection? Could something we inhale trigger the condition?

 

Once the damage starts, the damaged condition seems to contribute to further damage.

This damage can begin early in life but happen so gradually it isn't noticable until later in life.

[Michaelangelica]

New Compound Identifies Alzheimer's Disease Brain Toxins, Study Shows

 

ScienceDaily (Mar. 28, 2008) — A groundbreaking study conducted by University of Pittsburgh Alzheimer's disease researchers reported in the journal Brain confirms that Pittsburgh Compound-B (PiB) binds to the telltale beta-amyloid deposits found in the brains of patients with Alzheimer's disease. The finding is a significant step toward enabling clinicians to provide a definitive diagnosis of Alzheimer's disease in living patients.

Until now, the beta-amyloid deposits to which PiB binds have been confirmed, without question, only in the autopsied brains of patients afflicted with Alzheimer's.

The new findings, which correlate PiB-identified beta-amyloid deposits from living patients to their post-mortem autopsy results, will ultimately aid in the early diagnosis of Alzheimer's, help clinicians monitor the progression of the disease and further the development of potential treatments.

 

"This is final confirmation of what we have believed all along -- that Pittsburgh Compound-B allows us to accurately assess the amount of beta-amyloid plaques in brains of people afflicted with Alzheimer's,"

New Compound Identifies Alzheimer's Disease Brain Toxins, Study Shows

 

[Michaelangelica]

Brits Make Alzheimer’s a Medical Priority

28/03/2008

 

Alzheimer's Disease moves up the list as the public and NHS identify top health spending concerns.

 

In a new survey the UK public has identified which illnesses should be a priority for national health spending, 72% of people say cancer is a national priority, according to research from the ABPI.

 

A third of people cite heart disease, widely regarded as the second most prevalent and debilitating illness, and Alzheimer's is now the third most cited disease with 11% of the UK public demanding greater national health spending for the disease.

This means public concern over the need for greater investment in care, treatment and research into Alzheimer's disease has reached an unprecedented level.

KeepTheDoctorAway - Brits Make Alzheimer?s a Medical Priority

That 'concern' does not seem to have been translated into money for research.

 

March 26, 2008 It is estimated that around 4.5 million people in the US are currently living with Alzheimer's and the disease is one of the leading causes of death, accounting for tens of thousands each year. There has been no definitive way of diagnosing the disease on living patients so doctors have had to rely on medical histories, administering physical exams, and neuropsychological assessments. Now a team of researchers in Massachusetts has developed a way of examining brain tissue with near-infrared light to detect signs of Alzheimer's disease.

Alzheimer's detection using near-infrared light

 

Lilly trial will test drug for Alzheimer's | IndyStar.com | The Indianapolis Star

Lilly to trial new drug.

[Michaelangelica]

Brits Make Alzheimer’s a Medical Priority

28/03/2008

 

Alzheimer's Disease moves up the list as the public and NHS identify top health spending concerns.

 

In a new survey the UK public has identified which illnesses should be a priority for national health spending, 72% of people say cancer is a national priority, according to research from the ABPI.

 

A third of people cite heart disease, widely regarded as the second most prevalent and debilitating illness, and Alzheimer's is now the third most cited disease with 11% of the UK public demanding greater national health spending for the disease.

This means public concern over the need for greater investment in care, treatment and research into Alzheimer's disease has reached an unprecedented level.

KeepTheDoctorAway - Brits Make Alzheimer?s a Medical Priority

That 'concern' does not seem to have been translated into money for research.

 

March 26, 2008 It is estimated that around 4.5 million people in the US are currently living with Alzheimer's and the disease is one of the leading causes of death, accounting for tens of thousands each year.

 

There has been no definitive way of diagnosing the disease on living patients so doctors have had to rely on medical histories, administering physical exams, and neuropsychological assessments. Now a team of researchers in Massachusetts has developed a way of examining brain tissue with near-infrared light to detect signs of Alzheimer's disease.

Alzheimer's detection using near-infrared light

 

Lilly trial will test drug for Alzheimer's | IndyStar.com | The Indianapolis Star

Lilly to trial new drug.

 

Unexpected Discovery Made by Swedish Researchers within the Field of Alzheimer: Newly Discovered Protein Inhibits the Formation of the Precursor to Alzheimer's Plaques

 

STOCKHOLM, Sweden, March 27, 2008. As of today, there is no cure or effective treatment of Alzheimer's disease. Swedish researchers have now through their discoveries opened up new possible strategies for potential treatment of the actual cause of the disease. These results have been obtained through a fruitful collaboration between researchers from Sahlgrenska Academy at University of Gothenburg, Royal Institute of Technology (Kungliga Tekniska Högskolan, KTH) and the company Affibody AB

.

PharmaLive: Unexpected Discovery Made by Swedish Researchers within the Field of Alzheimer: Newly Discovered Protein Inhibits the Formation of the Precursor to Alzheimer's Plaques

 

Protecting Against Alzheimer's Disease

A number of studies have suggested that curcumin, the biologically active constituent in turmeric, protects against Alzheimer's disease by turning on a gene that codes for the production of antioxidant proteins.

A study published in the Italian Journal of Biochemistry (December 2003) discussed curcumin's role in the induction of the the heme oxygenase pathway, a protective system that, when triggered in brain tissue, causes the production of the potent antioxidant bilirubin, which protects the brain against oxidative (free radical) injury. Such oxidation is thought to be a major factor in aging and to be responsible for neurodegenerative disorders including dementias like Alzheimer's disease.

The most active ingredient in turmeric root, bisdemethoxycurcumin, boosts the activity of the immune system in Alzheimer's patients, helping them to clear the amyloid beta plaques characteristic of the disease.

Natural Health Remedies: Tumeric

There we are Terry a nice curry; much tastier than a badger's bum.

 

Washed down with some brown ale?

From Food and Chemical Toxicology, volume 46 issue 1, January 2008:

 

Aluminium (Al), a neurotoxin, has lately been implicated as one of the possible causal factors contributing to Alzheimer’s disease. Because silicon (Si) intake can affect the bioavailability of aluminium, the object of the present study was to assess whether moderate beer consumption might, as a source of dietary Si, affect the toxicokinetics of Al and thereby limit that element’s neurotoxicity.

 

The results obtained confirmed that at moderately high levels of beer intake the Si present in the beer was able to reduce Al uptake in the digestive tract and thus was able to slow the accumulation of this metal in the body, brain tissue included.

 

In consequence, moderate beer consumption, due to its content in bioavailability silicon, possibly affording a protective factor for preventing Alzheimer’s disease, could perhaps be taken into account as a component of the dietary habits of the population.

Josh Reviews Everything: BREAKING NEWS

[Michaelangelica]

This looks like an important breakthrough in understanding and stopping the mechanisms of Alzehimer's

04-07-2008 02:07

Mechanism Behind Alzheimer’s Disease Clarified

Mechanism Behind Alzheimer?s Disease Clarified

"The outcome implies we can deter the neural impairment in the brain by Abeta without causing further deterioration to brain functions by finding the substance blocking the effect of synaptogenin 1," the study said.

[Monomer]

It seems that there's always something on new on Alzheimer's Disease:

 

Diabetes in Middle Age Raises Alzheimer's Risk

 

The study included nearly 2,300 Swedish men who had glucose testing at age 50 to check for diabetes, a metabolic disease caused by abnormal insulin levels. The men were then followed for 32 years. The results: 102 were diagnosed with Alzheimer's disease, 57 with vascular dementia, and 235 with other types of dementia or cognitive impairment, the researchers said.

 

The study found that the men with low insulin levels at age 50 were nearly one-and-a-half times more likely to develop Alzheimer's disease than men who didn't have insulin problems. The risk of Alzheimer's increased, regardless of blood pressure, cholesterol, body-mass index and education.

 

"Our results suggest a link between insulin problems and the origins of Alzheimer's disease and emphasize the importance of insulin in normal brain function," Ronnemaa said. "It's possible that insulin problems damage blood vessels in the brain, which leads to memory problems and Alzheimer's disease, but more research is needed to identify the exact mechanisms."

 

And a possible link between depression and Alzheimer's:

 

Depression has been linked to an increased risk of Alzheimer's, and many researchers have suspected that risk is tied to changes in the brain caused by depression. The theory has been that depression shrinks specific areas, leaving the brain vulnerable to the development of Alzheimer's. However, this study found that's not the case.

 

"We don't know yet whether depression contributes to the development of Alzheimer's disease or whether another unknown factor causes both depression and dementia," lead researcher Dr. Monique M.B. Breteler, from the Erasmus University Medical Center in Rotterdam, the Netherlands, said in a statement. "We'll need to do more studies to understand the relationship between depression and dementia."

[Michaelangelica]

An (illegal) cross post from "Fragrance and perfume thread

The World Today - Scientists use smell tests to detect brain disorders

Quote:

Scientists use smell tests to detect brain disorders

PRINT FRIENDLY EMAIL STORY

The World Today - Tuesday, 5 December , 2006 12:46:00

Reporter: Annie Guest

ELEANOR HALL: A new study published today reveals that when it comes to degenerative brain disorders, the nose knows.

 

Australian scientists are promising a new era in the detection of brain disorders like Alzheimer's, with diagnosis through smell tests.

 

The University of Melbourne team has discovered a link between an inability to identify odours and at least five diseases, as Annie Guest reports.

 

ANNIE GUEST: People with mental illnesses are often shunned. Sometimes an inability to care for their hygiene needs further isolates them.

 

But it was that very problem that was the genesis for the research by Associate Professor Warwick Brewer.

__________________

[Michaelangelica]

A cup of coco

A glass of wine

It is all starting to sound promising every day.

So long as we get another 20-30 books out of Terry pratchett I'll be happy!

 

Alzheimer’s Vaccine and Early Detection Process Show Promise

Researchers at the University of California, Irvine, have been testing a promising vaccine designed to clear beta-amyloid plaques from the brain. In an article in Today at UCI, titled”Alzheimer’s vaccine clears plaque but has little effect on learning and memory impairment,” researchers say that what they’ve found is that the vaccine does what it was intended to do. That’s the good news. However, they also found that…

Carol Bradley Bursack

 

New Type of Alzheimer?s Drug Shows Promise

The American Academy of Neurology 60th Annual Meeting brought news of a new Alzheimer’s drug called Dimebon. The drug just made it through a pivotal phase of testing. Although it faces more trials before it will be marketable, the information implies that Dimebon could prove to be an important part of future Alzheimer’s treatment. According to the press release: "After one year of therapy with Dimebon, Alzheimer’s…

Carol Bradley Bursack

 

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Alzheimer’s Disease - Symptoms,Treatment, Articles and News » Alzheimers Disease - Alzheimer’s Vaccine and Early Detection Process Show Promise

Lifelong Health: Early Treatment Can Slow Progress of Memory Loss

Dr. David Lipschitz

 

The Alzheimer's Association recently issued a report indicating that for adults who live beyond age 55, the lifetime risk of developing Alzheimer's disease averages 17 percent in women and 9 percent in men.

 

However, in the past several years many researchers have identified a form of memory decline referred to as minimal cognitive impairment that may provide early indication of more serious memory loss to come. A recent report published in the Annals of Internal Medicine showed that 22.2 percent of adults over the age of 71 have the impairment and as many as 12 percent of those develop significant memory loss annually.

 

Currently, 5.1 million Americans have Alzheimer's disease, but as the 78 million baby boomers reach the "Third Age" of life, the incidence of Alzheimer's disease will increase dramatically. The Alzheimer's Association projects that the number of adults with Alzheimer's disease will increase to 7.7 million in 2030 and 11 million to 16 million by 2050.

http://blog.360.yahoo.com/blog-dmuRZs0waagQPKgR4qjLSg--?cq=1&p=13013

[Dr.Erfan]

It is my first Post here and sorry if my English is not good, because it's not my native language:)

 

We are doing a research on Curing the Alzheimer's by some herbal drugs as I have done it for some people around me.

 

I hope the results change the future for people who are suffering from it:)

 

We will update you here:)

 

Have a good time.

[Michaelangelica]

What's New in Depression May 1, 2008

Alzheimer risk triple in a subset of depressed persons

 

How much do you need to worry that patients you are treating for depression will go on to develop Alzheimer disease (AD)? Two recently published studies raised further concerns about the association and seemed to underline the difficulty of making the diagnosis of AD ahead of time.

 

In the April 8 issue of Neurology, investigators from Erasmus Medical Center, Rotterdam, reported an increased risk for developing Alzheimer that was more than triple in patients who had early-onset depression and more than double in those who had late-onset depression.

iMarketing Automation

[Michaelangelica]

We look forward to your posts Dr.Erfan

 

Impaired Insulin Response Linked to Alzheimer's Disease

 

elderly, Alzheimer's diseaseImpaired insulin response appears to be involved in the development of Alzheimer's disease, according to a long-term population-based study.

 

Researchers analyzed data for more than 2,200 men who underwent glucose tolerance testing at the age of 50. After a follow-up at an average age of 32 years, 394 men developed dementia or mental impairments, including 102 with confirmed Alzheimer's disease and 57 with confirmed vascular dementia.

Impaired Insulin Response Linked to Alzheimer's Disease - Articles

[Michaelangelica]

Alzheimer's Disease Risks Gender Specific: Women With Depression, Men With Stroke

ScienceDaily (May 2, 2008) — The risks of developing Alzheimer's disease differ between the sexes, with stroke in men, and depression in women, critical factors, suggests research published ahead of print in the Journal of Neurology Neurosurgery and Psychiatry.

. . .

 

Just over one in three reverted to normal levels of cognitive agility. Progression from mild cognitive impairment to dementia was more likely among those who were depressed and who were taking anticholinergic drugs, which influence chemical signalling in the brain.

 

A variation in the ApoE gene, a known risk factor for dementia, was also more common among those whose mild cognitive impairment progressed. But risk factors also differed between the sexes, the results showed.

 

Men with mild cognitive impairment were more likely to be overweight, diabetic, and to have had a stroke. Men who had had a stroke were almost three times as likely to progress. Women with mild cognitive impairment were more likely to be in poorer general health, disabled, suffering from insomnia and to have a poor support network.

 

Women unable to perform routine daily tasks, which would allow them to live without assistance, were 3.5 times as likely to progress. And those who were depressed were twice as likely to do so. Stroke was not a risk factor for women, despite a similar rate of occurrence in both sexes.

Alzheimer's Disease Risks Gender Specific: Women With Depression, Men With Stroke

[Michaelangelica]

King Lear

One of the first documented Alzheimer's sufferers??

 

Pomegranates

I love pomegranates but rarely if ever eat them. I think they are more popular in the UK. They are such pretty fruit and trees and may help Alzheimer's.

SEE:-

Pomegranate sauce offers marinade potential for industry

and

Pomegranate juice may cut Alzheimer's risk

By Stephen Daniells

 

03-Oct-2006 - A daily glass of antioxidant-rich pomegranate juice could halve the build-up of harmful proteins linked to Alzheimer's disease, says a new animal study from the USA.

Pomegranate juice may cut Alzheimer's risk

 

 

Anyone want to summarise all the foods and wines that are good for Alzheimer's we have discovered so far?

how about The Hypography Alzheimer's Cookbook"?:esmoking:

New B12 Delivery Offers Possible Help for Dementia and Alzheimer's

 

Download this press release as a PDF document.

 

FORT LAUDERDALE, Florida, April 30 /PRNewswire-HISPANIC PR WIRE/ -- Alzheimer's Disease touches many people. Statistics from the Alzheimer's Association indicate that as many as 5.2 million people in the United States are living with Alzheimer's and every 71 seconds, someone develops Alzheimer's, including Hispanics. It is a progressive condition that causes problems with memory, thinking and behavior severe enough to affect work, lifelong hobbies, or social life.

 

 

 

Many people are unaware that Alzheimer's is also a fatal disease. In fact, it is the seventh leading cause of death in the United States alone. Alzheimer's, along with other dysfunctions of memory and thinking known as dementia, typically rob families and individuals of happiness and the ability to live their senior years to the fullest. Therefore, the search is on to find treatments that can help slow down or reverse the onset of these brain disorders.

 

Many people are unaware that Alzheimer's is also a fatal disease

 

 

Research indicates that something as simple as vitamin B12 may be instrumental to that end, but the challenge has been finding ways to deliver B12 in sufficient quantities to the blood stream and cerebral spinal fluid. Now Nascobal® Nasal Spray, (Welcome to Nascobal - A QOL Medical Company) an FDA approved B12 product of QOL Medical, has been shown in clinical trials to significantly increase blood levels and to increase the CSF levels ten-fold when compared to the typical treatment of intramuscular injections.

 

Importance of B12

Vitamin B12 is an important vitamin for a person's health. It plays a vital role in the formation of red blood cells and in the health of nerve tissue. B12 works with folic acid in the synthesis of DNA and red blood cells and is important in maintaining the health of the insulation sheath (myelin sheath) that surrounds nerve cells. A deficit of B12 results in neurological dysfunction, including memory loss, trouble concentrating, anemia, and even vascular problems. Vitamin B12 deficiency is very common among older adults and those with stomach problems that compromise absorption of the vitamin.

Hispanic PR Wire - New B12 Delivery Offers Possible Help for Dementia and Alzheimer's

and

Welcome to Nascobal - A QOL Medical Company

[Michaelangelica]

Samaritan Pharmaceuticals (OTCBB:SPHC), a biopharmaceutical company committed to commercializing new innovative therapeutic drugs, has received notification that the claims in the patent application for "Neuroprotective Spirostenol Pharmaceutical Compositions" covering Caprospinol (SP-233) have been allowed by the Australian Patent Office.

 

The hallmark of Alzheimer's disease is plaque formation in areas of the brain that control memory and thinking skills.

Plaque can cause swelling and bumps on nerve cells, making it hard or even impossible for the cells to communicate.

While the cause of Alzheimer's disease still remains unknown, a growing number of researchers are indicating that plaque formation and accumulation may play a role.

 

Caprospinol Studies:

 

Caprospinol cleared beta-amyloid plaque formation and restored memory capacity in-vivo, confirming in-vitro studies showing Caprospinol binds beta-amyloid directly and inhibits the formation of neurotoxic amyloid-derived diffusible ligands (ADDLs) by forming stable heavy complexes with the peptide.

In addition, the studies demonstrated Caprospinol protects mitochondria function, thus protecting cell viability and decreased cell death.

Studies have demonstrated Caprospinol may not only slow down Alzheimer's but may also reverse plaque-related brain injuries associated with the mind-robbing disease of Alzheimer's

Patent Claims Allowed Covering Samaritan's Alzheimer's Memory Recovery Drug In Australia

[HydrogenBond]

I like to speculate. If you look at depression, it narrows the mind. For example, one may lose interests, meaning the range of thinking sort of defaults to the psycho-drama loop associated with the depression. It may also limit physical activity and the blood pumped to the brain. If we combine this with the correlation that keeping the mind active helps to prevent Alzheimer's, one can see a connection between conscious focus, and system wide neurons usage or not. The depression implies system wide neural atrophy because the mind is not exercising memory. A study might address whether Alzheimer's patients stemming from depression are able to remember their depression better than other memory.

[Monomer]

Flavonoids May Help Treat Alzheimer's

 

Flavonoids, compounds found in many fruits and vegetables, may be able to battle the ravages of Alzheimer's disease, a new study suggests.

 

In experiments with mice, two flavonoids called luteolin and diosmin reduced levels of beta-amyloid, which forms the harmful plaques that build up in the brains of those with Alzheimer's disease.

 

The research team would like to use the two flavonoids to see if they can reduce amyloid plaque in humans, since they believe flavonoids would be safe and have few side effects compared with drugs that are being developed to reduce amyloid plaque.

 

Rezai-Zadeh also thinks that flavonoids, which have strong antioxidant properties, might guard against Alzheimer's. "A lot of these compounds can be derived from the diet, and they may have preventive effects against Alzheimer's disease," he said. "Increasing the flavonoids in your diet may help reduce the risk of Alzheimer's."

 

"The question is, can we use these flavonoids in people that have cognitive impairment?" Rezai-Zadeh said. "That's the million-dollar question."

 

In the study, Rezai-Zadeh's team used a mouse model of Alzheimer's disease to test their theory. Using, luteolin and diosmin, the researchers were able to reduce the levels of beta-amyloid in the rodents' brains.

 

In addition, the researchers found these two molecules were targeting a protein called presenilin-1, which has been linked to a genetic cause of Alzheimer's disease. These findings could lead to a new approach for treating Alzheimer's patients, they said.

[Michaelangelica]

Listen Now - 12052008 |Download Audio - 12052008

 

A recent study by French researchers suggests that the risk of developing Alzheimer's disease differs between the sexes, with stroke in men and depression in women being critical factors. And a group of researchers in Canada have come up with a set of tests which seem to be able to give a high degree of confidence that someone has Alzheimer's.

 

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